CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection

Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for clearance during systemic C. albican infection, yet little has been known regarding which surface receptor controls neutrophils’ antifungal activities. CD137, is encoded Tnfrsf9, belongs to the tumor necrosis superfamily and shown regulate neutrophils Gram-positive bacterial infection. Here, we used genetic immunological tools probe involvement of neutrophil CD137 signaling innate defense mechanisms against We first found that Tnfrsf9−/− mice were susceptible whereas injection anti-CD137 agonistic antibody protected host from suggesting indispensable immunity Priming isolated with promoted their phagocytic fungicidal activities through phospholipase In addition, significantly augmented restriction growth received wild-type (WT) neutrophils. conclusion, our results demonstrate contributes infection promoting rapid clearance.